Cheesy Chicken Pot Pie Bubble-Up Casserole – Easy Family Comfort Food Recipe

If you’re craving something cheesy, creamy, and undeniably comforting, then let me introduce you to your next go-to dinner recipe: Chicken Pot Pie Bubble-Up Casserole. It’s the ultimate cozy casserole—everything you love about a classic pot pie, but with a fun twist thanks to those fluffy, golden biscuits that “bubble up” as they bake. Whether you’re cooking for picky kids, hungry teens, or just want something ultra-satisfying after a long day, this dish checks all the boxes.

This isn’t just another casserole—this is chicken pot pie reimagined. A marriage of rich and creamy filling, savory shredded chicken, tender vegetables, and buttery biscuit pieces baked to golden perfection. Not to mention, it comes together with pantry staples and refrigerated biscuit dough for a no-fuss, ultra-flavorful meal that’ll have the whole family asking for seconds.

In this article, we’re diving deep into everything you need to know about Chicken Pot Pie Bubble-Up Casserole—from its ingredients and variations to expert tips, freezer-friendly options, and mouthwatering serving suggestions. Let’s get started.

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Why You’ll Fall in Love with Chicken Pot Pie Bubble-Up Casserole

Let’s be real—casseroles are one of the best inventions to come out of any kitchen. They’re hearty, filling, often made with leftovers, and usually baked all in one dish. But the Chicken Pot Pie Bubble-Up Casserole? This one is special.

Here’s why we’re obsessed with it:

• Easy ingredients you likely already have at home.
• Ready in under an hour—perfect for busy weeknights.
• That “bubble-up” magic as the biscuit dough rises into golden, buttery perfection.
• A crowd-pleaser that kids and adults devour alike.
• It’s the ultimate comfort food—warm, cheesy, creamy, and satisfying.

If your dinner rotation is feeling stale, this Chicken Pot Pie Bubble-Up Casserole will breathe new life into it.

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What Is a Bubble-Up Casserole, Anyway?

The name might sound a little funny at first, but the idea is genius. A bubble-up casserole gets its name from the refrigerated biscuit dough that’s chopped and stirred into the filling before baking. As the casserole bakes, the biscuits “bubble up” through the creamy mixture, puffing into golden nuggets of bready deliciousness.

Instead of rolling out a crust or layering ingredients, the biscuits do all the work—adding structure, fluff, and texture to each bite. It’s a clever shortcut with a delicious payoff.

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Ingredients You’ll Need

To make this cheesy Chicken Pot Pie Bubble-Up Casserole, you’ll need simple, everyday ingredients that deliver maximum flavor with minimum effort:

Main Ingredients:

• 2 cups cooked, shredded chicken – Rotisserie chicken works great!
• 1 can cream of chicken soup – Adds that rich, creamy texture.
• 1 cup sour cream – Creamy and tangy.
• 1 cup shredded cheddar cheese – Go for sharp cheddar for bold flavor.
• 1½ cups mixed frozen vegetables – Peas, carrots, corn, and green beans are ideal.
• 1 tsp garlic powder – A little garlic punch never hurts.
• ½ tsp seasoned salt – Adds depth of flavor.
• 2 cans refrigerated biscuits (6 oz each) – The bubbly stars of this show.

Optional Add-Ins:

• A pinch of black pepper or smoked paprika
• Chopped fresh parsley for garnish
• Diced onion if you want more savory flavor
• A handful of cooked bacon bits for extra indulgence

These ingredients are easy to customize, and that’s part of what makes this Chicken Pot Pie Bubble-Up Casserole such a winner—it’s endlessly adaptable.

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How to Make Chicken Pot Pie Bubble-Up Casserole (Step-by-Step)

This recipe is designed to be as simple as possible, while still tasting like you spent all day cooking.

Step 1: Preheat the Oven

Set your oven to 375°F (190°C) and grease a 9×13-inch baking dish with cooking spray or a bit of butter.

Step 2: Make the Filling

In a large mixing bowl, combine:

• 2 cups cooked, shredded chicken
• 1 can of cream of chicken soup
• 1 cup of sour cream
• 1 cup shredded cheddar cheese
• 1½ cups frozen mixed vegetables
• 1 tsp garlic powder
• ½ tsp seasoned salt

Stir everything together until well combined.

Step 3: Cut the Biscuits

Pop open those refrigerated biscuit cans and cut each biscuit into quarters. Gently fold the biscuit pieces into the chicken mixture until they’re evenly distributed.

Step 4: Assemble the Casserole

Pour the biscuit-filled mixture into your greased baking dish. Spread it out into an even layer and resist the urge to press down too hard—you want the biscuits to rise and bubble up freely.

Step 5: Bake

Place the casserole in the preheated oven and bake for 35 to 45 minutes, or until the biscuits are golden brown and cooked through. The top should be lightly crisp, while the inside is bubbly and gooey.

Step 6: Cool and Serve

Let your casserole sit for 5 to 10 minutes before serving. This helps everything set and makes it easier to slice and serve.

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Tips for the Best Chicken Pot Pie Bubble-Up Casserole

Want to make sure your casserole is absolute perfection? Here are some top tips:

1. Pre-cook Your Chicken

Using pre-cooked or rotisserie chicken saves time and ensures juicy meat. If cooking your own, season it well beforehand.

2. Thaw the Veggies

Frozen veggies can water down your casserole. Let them thaw a bit and pat dry before mixing.

3. Don’t Over-Stir the Biscuits

Once they’re added, fold gently. Overmixing can cause them to break apart too much and affect how they rise.

4. Use Sharp Cheddar

The tangy flavor of sharp cheddar adds depth that milder cheeses can’t match.

5. Add a Crispy Topping

Sprinkle extra cheese or breadcrumbs on top during the last 10 minutes of baking for a crunchy golden crown.

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Make-Ahead, Freezing & Storing Tips

This Chicken Pot Pie Bubble-Up Casserole is fantastic for meal prep. Here’s how to make it work:

Make-Ahead:

Assemble the casserole up to the point of baking, cover tightly, and refrigerate for up to 24 hours.

Freezing:

Wrap the unbaked casserole tightly with foil and plastic wrap and freeze for up to 3 months. Bake directly from frozen, adding an extra 15–20 minutes of baking time.

Leftovers:

Store leftovers in an airtight container in the fridge for up to 4 days. Reheat in the oven or microwave until warmed through.

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Serving Suggestions: What to Eat With It

This dish is a meal all on its own, but if you want to round it out, here are some ideas:

• Simple green salad with vinaigrette
• Roasted asparagus or Brussels sprouts
• Mashed sweet potatoes
• Garlic green beans
• A warm dinner roll (because you can never have too many carbs)

You can also drizzle a little hot sauce or gravy over your slice for added flavor.

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Fun Variations to Try

Ready to mix it up? Here are some fun ideas to customize your Chicken Pot Pie Bubble-Up Casserole:

Tex-Mex Bubble-Up

Swap cheddar for pepper jack, use Mexican corn and black beans, and add taco seasoning.

Buffalo Chicken Version

Mix buffalo sauce into the filling and top with blue cheese crumbles.

Ham and Cheese Casserole

Sub out chicken for diced ham, use Swiss or Gruyère cheese, and add broccoli florets.

Turkey Pot Pie Bubble-Up

Perfect for Thanksgiving leftovers—just replace the chicken with cooked turkey.

The base recipe is flexible, and once you make it once, you’ll probably start dreaming up your own versions!

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Healthier Ingredient Swaps

If you want to lighten up this Chicken Pot Pie Bubble-Up Casserole without sacrificing flavor, try these:

• Use light sour cream or Greek yogurt
• Try reduced-fat cheddar
• Choose low-sodium cream of chicken soup
• Swap whole wheat biscuit dough if available
• Add extra vegetables to increase fiber and nutrients

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FAQs: Chicken Pot Pie Bubble-Up Casserole

Can I use homemade biscuit dough instead of canned?

Absolutely! If you prefer from-scratch dough, go for it. Just make sure to cut it into small pieces so it cooks evenly.

How do I know the biscuits are fully cooked?

The top should be golden and slightly crisp. Insert a toothpick or knife into the center—if it comes out clean and the biscuits aren’t doughy, you’re good to go.

Can I make this vegetarian?

Yes! Just leave out the chicken and double up on veggies or use a plant-based chicken alternative.

What’s the best cheese to use?

Sharp cheddar is classic, but feel free to mix in Monterey Jack, mozzarella, or even cream cheese for extra richness.

Can I use fresh veggies instead of frozen?

Definitely—just make sure to steam or sauté them a bit first so they’re not too crunchy in the finished dish.

Can this casserole be cooked in a slow cooker?

Not ideal. The biscuits won’t get that golden “bubble-up” finish. Stick to the oven for best results.

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Conclusion: The Ultimate Comfort Food for Any Night of the Week

There’s just something magical about a warm, cheesy, creamy casserole fresh from the oven—and this Chicken Pot Pie Bubble-Up Casserole delivers that and more. It’s easy, budget-friendly, customizable, and absolutely packed with flavor. Whether you’re feeding a family, meal prepping for the week, or just craving serious comfort food, this dish has you covered.

From its gooey, golden top to the creamy, savory center, every bite is pure joy. Add this Chicken Pot Pie Bubble-Up Casserole to your recipe rotation and you’ll wonder how you ever lived without it. Trust us—this one’s a keeper.

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